Lab Funding

R21HL108052

(PI: Foster, Co-PI: O’Rourke)

08/27/12-08/26/14

NIH/NHLBI
Role: Principal Inv.
A Systems Biology Approach to Cardiomyopathy in a D. melanogaster Model
The primary goal is to map the retrograde signaling from cardiomyopathy mutations using a quantitative proteomic approach

12SDG12060056

AHA National Scientist Development Grant   (PI: Foster)

07/01/12-06/30/16

AHA/Nat. Center
Role: Principle Inv.
Characterizing MitoROMK, the K+ channel subunit of MitoKATP
This project aims to capitalize on the discovery of MitoROMK, to find and validate both binding partners and post-translational modifications of the pore-forming and regulatory subunits of MitoKATP.

R01HL101235-01

(PIs: O’Rourke, Bers, Blatter, Van Eyk, Trayanova)

05/01/10-04/31/15

NIH/NHLBI
Role: Co-Inv.
Mitochondrial dysfunction in cardiac hypertrophy and failure
This project investigates the links between ROS/NO balance, mitochondrial Ca2+ dynamics and protein modification in a guinea-pig pressure overload hypertrophy/failure model.

R01HL108917

(PI: O’Rourke)

07/01/11-06/30/16

NIH/NHLBI
Role: Co-Inv.
Novel Mitochondrial Ion Transporters
This project will characterize the functional role of novel mitochondrial ion transporters and channels detected by proteomic analysis.

HHSN268201000032C

JHU/NHLBI Proteomics Center Contract (PI: Van Eyk)

09/01/10-08/31/16

NIH/NHLBI
Role: Co-Inv.
Proteomics of Heart Failure: Mitochondrial acetylation in HF
on Application Project 4: (PI: O’Rourke, collaborator Cotter)
The overall goals of this grant are to study the proteomics of heart failure. Specific project is to analyze acetylation pattern of mitochondrial proteins during HF progression.

Completed or Declined

12BGIA11880002

Beginning Grant-in-Aid (PI: Foster)

Awarded and Declined, June 2012

AHA/Mid-Atlantic
Role: Principal Inv.
A Systems Biology Approach to Cardiomyopathy using D. melanogaster as a Model System
The primary goal is to map the retrograde signaling from cardiomyopathy mutations using a quantitative proteomic approach. It was declined to accept 12SDG12060056. The project was subsequently funded under R21HL108052

P01 HL081427

(PI: O’Rourke)

07/01/05-06/30/11

NIH/NHLBI
Role: Key Personnel
Mitochondrial Function in Ischemic Cardiac Disease
This PPG investigated, using molecular, computation, and proteomic methods, how mitochondrial function is remodeled during ischemia and reperfusion.

0120299T

AHA Postdoctoral Fellowship (PI: Foster)

07/01/01-06/30/03

AHA/Founders Affil.
Role: Principal Inv.
Structural Investigation of Muscle Thin Filaments Using 3D Helical Image Reconstruction of Electron Micrographs